Drug Delivery Systems

NOVEL DRUG DELIVERY SYSTEM: The method by which a drug is delivered can have a significant effect on its efficacy. Some drugs have an optimum concentration range within which maximum benefit is derived, and concentrations above or below this range can be toxic or produce no therapeutic benefit at all. On the other hand, the […]

PLGA

PLGA Poly(lactic-co-glycolic acid) (PLGA) is made from two monomers, lactic acid and glycolic acid. The ratio of the monomers and the molecular weight set the identity and properties. For example, PLGA 88:12 means the polymer is made of 88 percent lactic acid and 12 percent glycolic acid. Generally, the higher the percentage of lactide units, […]

Microsphere

Poly(D,L-lactide-co-glycolide) (PLGA) microspheres are biodegradable antigen delivery devices for loading of dendritic cells with antigen and toll-like receptor ligand in vitro and in vivo. They possess useful characteristics such as an adjustable drug release profile and a very high encapsulation efficiency. Dendritic cells efficiently take up the microspheres, process the microencapsulated antigens and present them […]